The US-led coalition and its convoluted operations in Syria and Iraq has led to thousands of civilian casualties so far. Syrian military base in Deir Ezzor was attacked September 17, 2016 by the US-led coalition’s warplanes. The base was missioned to make and implement plans to battle and defeat ISIS forces in multiple fronts. At least 62 Syrian soldiers were killed and many more injured during the attack. The attack against the Deir Ezzor base stopped after a Russian officer called the U.S. officials telling they were targeting a Syrian base not ISIS. Only minutes after the operations were called off, ISIS waged an attack seizing the base. The United States later apologized for what they claimed as a fallacy in attacking wrong base using Russia as an intermediator. One Question, however, remained unanswered since then. Bashar Al-Assad, the Syrian president, questioned the unintentional nature of attack against Der Ezzor base in an interview with Associated Press: “The ISIS troops attacked right away after the American strike,” How could they know that the Americans are going to attack that position in order to gather their militants to attack right away and to capture it one hour after the strike? Assad’s question could only have one implication; there is a latent and secretive cooperation between US and ISIS. Since then, many other attacks were raged against Syrian or Iraqi forces by the US-led coalition. The US strategy was either denial of the attack or linking it with decimation of ISIS forces. The recurrence of these attacks got more intense after multiple defeat of ISIS forces in different cities of Syria and Iraq like Aleppo and Mosul. Three months ago, the US attacked Popular Mobilization Unit, a branch of Iraqi army, using the false flag of attacking ISIS. The attack was recurred a couple of weeks ago after the PMU forces were attacked by US warplanes near the Syrian borders. The US attack in the morning was followed by ISIS attacks in the afternoon leading to the death of a large group of Iraqi soldiers. Evidences truly show the role of Americans in hindering the quick defeats of ISIS in different fronts. The US-led coalition has lent little help so far while the number of civilian casualties during the years proved high.